The study of cancer growth mechanisms and the determination of the efficacy of experimental therapeutics are usually performed in 2D cell culture models. However, these models are incapable of mimicking complex interactions between cancer cells and the environment. With the advent of microfluidic technologies, the combination of multiple cell cultures with mechanical and biochemical stimuli has enabled a better recapitulation of the 3D tumor environment using minute amounts of reagents. These models can also be used to study drug transport, hypoxia, and interstitial pressure within the tumor. In this review, we highlight the applications of microfluidic-based models in anticancer drug studies and provide a perspective on the future of the clinical applications of microfluidic systems for anticancer drug development.
Karolina P. Valente1, S. Khetani2, A.R. Kolahchi2, A. Nezhad2, Afzal Suleman1, Mohsen Akbari1, 3, 4, ,
1 Department of Mechanical Engineering, University of Victoria, Victoria, BC, V8P 5C2, Canada
2 Department of Mechanical and Manufacturing Engineering, University of Calgary, Calgary AB, T2N 1N4, Canada
3 Center for Biomedical Research, University of Victoria, Victoria, BC, V8P 5C2, Canada
4 Center for Advanced Materials and Related Technologies, University of Victoria, Victoria, BC, V8P 5C2, Canada
Available online 4 July 2017