The microfluidic technique has brought unique opportunities toward the full control over the production processes for drug delivery carriers, owing to the miniaturisation of the fluidic environment. In comparison to the conventional batch methods, the microfluidic setup provides a range of advantages, including the improved controllability of material characteristics, as well as the precisely controlled release profiles of payloads. This review gives an overview of different fluidic principles used in the literature to produce either polymeric microparticles or nanoparticles, focusing on the materials that could have an impact on drug delivery. We also discuss the relations between the particle size and size distribution of the obtained carriers, and the design and configuration of the microfluidic setups. Overall, the use of microfluidic technologies brings exciting opportunities to expand the body of knowledge in the field of controlled drug delivery and great potential to clinical translation of drug delivery systems.
Dongfei Liu,*ab Hongbo Zhang,bc Flavia Fontana,a Jouni T. Hirvonena and Hélder A. Santos*ad
* Corresponding authors
a Division of Pharmaceutical Chemistry and Technology, Drug Research Program, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland
E-mail: firstname.lastname@example.org, email@example.com
b John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, USA
c Department of Pharmaceutical Science, Åbo Akademi University, FI-20520 Turku, Finland
d Helsinki Institute of Life Science, HiLIFE, University of Helsinki, FI-00014 Helsinki, Finland