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[Journal of Organic Chemistry] Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction

March 24, 2017



A versatile continuous-flow synthesis of highly functionalized 1,2,4-oxadiazoles starting from carboxylic acids is reported. This process was applied to the multistep synthesis of imidazo[1,2-a]pyridin-2-yl-1,2,4-oxadiazoles, using a three reactor, multistep continuous-flow system without isolation of intermediates. This continuous-flow method was successfully combined with a single-step liquid–liquid microextraction unit to remove high boiling point polar solvents and impurities and provides the target compounds in high purity with excellent overall yields.


Ananda Herath and Nicholas D. P. Cosford

Cancer Metabolism & Signaling Networks Program, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, California 92037, USA

 Corresponding author email     

This article is part of the Thematic Series "Automated chemical synthesis".

Guest Editor: I. R. Baxendale

Beilstein J. Org. Chem. 2017, 13, 239–246.



Link: http://www.beilstein-journals.org/bjoc/single/articleFullText.htm?publicId=1860-5397-13-26

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