© 2017 by "Microfluidics News". 

Topics
News Archives
Please reload

[Conference]Bioinspired vascular structures via 3D printing and suspended microfluidics

March 4, 2017

Abstract:

 

Accurate modeling of the complex three-dimensional (3D) microarchitectures of in vivo vascular structures has remained a formidable challenge for medical and biological communities. Although many platforms have been developed to mimic vascular microgeometry, difficulties associated with recreating in vivo characteristics such as permeability and tortuosity has impeded progress. To address these issues, here we present a novel strategy that combines additive manufacturing or “3D printing” with suspended microfluidics to fabricate semipermeable, tubular structures with tortuous architectures. Specifically, the approach entails: (i) using PolyJet 3D printing to create a tubular framework comprising local microcurvature and global tortuosity, and then (ii) employing a suspended microfluidics technique to coat the framework with a porous, biocompatible cellular scaffold. Fabricated proof-of-concept tubular scaffolds exhibited inner radii on the order of 100 μm. Experimental results revealed tubular rupture pressures in the range of approximately 30–65 kPa. Seeding of human umbilical vein endothelial cells (HUVECs) within the tubule suggests that the presented work could be extended to better model the micro/mesoscale architectures of vascular systems for applications including drug discovery, disease modeling, and personalized medicine.

 

Published in: Micro Electro Mechanical Systems (MEMS), 2017 IEEE 30th International Conference on MEMS

Date of Conference: 22-26 Jan. 2017

Date Added to IEEE Xplore: 28 February 2017

DOI: 10.1109/MEMSYS.2017.7863433

 

Joseph G. Dawson

Department of Mechanical Engineering, University of Maryland, College Park, MD, USA

David C. Hesley

Department of Mechanical Engineering, University of Maryland, College Park, MD, USA

Noriko Katagiri

Department of Mechanical Engineering, University of Maryland, College Park, MD, USA

Connie P. Nguyen

Department of Mechanical Engineering, University of Maryland, College Park, MD, USA

Stacey A. Mannuel

Department of Mechanical Engineering, University of Maryland, College Park, MD, USA

Tiffany G. Wun

Department of Mechanical Engineering, University of Maryland, College Park, MD, USA

Amanda B. Chow

Department of Mechanical Engineering, University of Maryland, College Park, MD, USA

Navin R. Gupta

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Joseph V. Bonventre

Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA

Ryan D. Sochol

Department of Mechanical Engineering, University of Maryland, College Park, MD, USA

 

Link: http://ieeexplore.ieee.org/abstract/document/7863433/

Share on Facebook
Share on Twitter
Please reload

Follow "Microfluidics News"