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[Patent] IN VITRO GASTROINTESTINAL MODEL COMPRISING LAMINA PROPRIA-DERIVED CELLS


Abstract:

An in vitro microfluidic gut-on-chip is described herein that mimics the structure and at least one function of specific areas of the gastrointestinal system in vivo. In particular, a multicellular, layered, microfluidic culture is described, allowing for interactions between lamina propria-derived cells and gastrointestinal epithelial cells and endothelial cells. This in vitro microfluidic system can be used for modeling inflammatory gastrointestinal tissue, e.g., Crohn's disease, colitis and other inflammatory gastrointestinal disorders. These multicellular, layered microfluidic gut-on-chip further allow for comparisons between types of gastrointestinal tissues, e.g., small intestinal deuodejeum, small intestinal ileium, large intestinal colon, etc., and between disease states of gastrointestinal tissue, i.e. healthy, pre-disease and diseased areas. Additionally, these microfluidic gut-on-chips allow identification of cells and cellular derived factors driving disease states and drug testing for reducing inflammation.

Document Type and Number:

United States Patent Application 20180230417

Kind Code: A1

Kerns, Jordan S. (Reading, MA, US) Obrigewitch, Jenifer (Boston, MA, US) Salmon, Michael (Boston, MA, US) Umiker, Benjamin Richards (Cambridge, MA, US)

Application Number:

15/820011

Publication Date:

08/16/2018

Filing Date:

11/21/2017

Link: http://www.freepatentsonline.com/y2018/0230417.html

#08272018 #organonachip #drug

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