[Angewandate Chemie] Cascades in Compartments: En route to Machine-Assisted Biotechnology
Biological compartmentalization is a fundamental principle of life that allows cells to metabolize, propagate or communicate with their environment. Much research is devoted to the understanding of this basic principle and to harness biomimetic compartments and catalytic cascades as tools for technological processes. We summarize the current state-of-the-art of these developments with a special emphasis on length scales, mass transport phenomena and molecular scaffolding approaches, ranging from small crosslinkers over proteins and nucleic acids to colloids and patterned surfaces. We conclude that the future exploration and exploitation of these complex systems will largely benefit from technical solutions for the integrated, machine-assisted development and maintenance of a next generation of biotechnological processes. These goals should be achievable by implementing microfluidics, robotics and added manufacturing techniques supplemented by theoretical simulations and computer-aided process modeling on the basis of big data obtained from multiscale experimental analyses.
Kersten S. Rabe, Joachim Müller, Marc Skoupi, Christof M. Niemeyer Accepted manuscript online: 10 July 2017Full publication history DOI: 10.1002/anie.201703806 View/save citation Cited by (CrossRef): 0 articles