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[Diagnostics] Advancing Point-of-Care (PoC) Testing Using Human Saliva as Liquid Biopsy


Abstract:

Salivary diagnostics is an emerging field for the encroachment of point of care technology (PoCT). The necessity of the development of point-of-care (PoC) technology, the potential of saliva, identification and validation of biomarkers through salivary diagnostic toolboxes, and a broad overview of emerging technologies is discussed in this review. Furthermore, novel advanced techniques incorporated in devices for the early detection and diagnosis of several oral and systemic diseases in a non-invasive, easily-monitored, less time consuming, and in a personalised way is explicated. The latest technology detection systems and clinical utilities of saliva as a liquid biopsy, electric field-induced release and measurement (EFIRM), biosensors, smartphone technology, microfluidics, paper-based technology, and how their futuristic perspectives can improve salivary diagnostics and reduce hospital stays by replacing it with chairside screening is also highlighted. View Full-Text

Rabia Sannam Khan 1, Zohaib Khurshid 2,* OrcID and Faris Yahya Ibrahim Asiri 3 1 Department of Oral Pathology, College of Dentistry, Baqai University, Super Highway, P.O.Box: 2407, Karachi 74600, Pakistan 2 Prosthodontics and Implantology, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia 3 Department of Preventive Dentistry, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia * Author to whom correspondence should be addressed. Received: 30 May 2017 / Revised: 24 June 2017 / Accepted: 30 June 2017 / Published: 4 July 2017

Link: http://www.mdpi.com/2075-4418/7/3/39

#07102017 #pointofcare #Biologicalapplication

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