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[Diagnostics] Advancing Point-of-Care (PoC) Testing Using Human Saliva as Liquid Biopsy


Salivary diagnostics is an emerging field for the encroachment of point of care technology (PoCT). The necessity of the development of point-of-care (PoC) technology, the potential of saliva, identification and validation of biomarkers through salivary diagnostic toolboxes, and a broad overview of emerging technologies is discussed in this review. Furthermore, novel advanced techniques incorporated in devices for the early detection and diagnosis of several oral and systemic diseases in a non-invasive, easily-monitored, less time consuming, and in a personalised way is explicated. The latest technology detection systems and clinical utilities of saliva as a liquid biopsy, electric field-induced release and measurement (EFIRM), biosensors, smartphone technology, microfluidics, paper-based technology, and how their futuristic perspectives can improve salivary diagnostics and reduce hospital stays by replacing it with chairside screening is also highlighted. View Full-Text

Rabia Sannam Khan 1, Zohaib Khurshid 2,* OrcID and Faris Yahya Ibrahim Asiri 3 1 Department of Oral Pathology, College of Dentistry, Baqai University, Super Highway, P.O.Box: 2407, Karachi 74600, Pakistan 2 Prosthodontics and Implantology, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia 3 Department of Preventive Dentistry, College of Dentistry, King Faisal University, Al-Ahsa 31982, Saudi Arabia * Author to whom correspondence should be addressed. Received: 30 May 2017 / Revised: 24 June 2017 / Accepted: 30 June 2017 / Published: 4 July 2017

Link: http://www.mdpi.com/2075-4418/7/3/39

#07102017 #pointofcare #Biologicalapplication

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