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[Chemical Communications] A membrane-anchored aptamer sensor for probing IFNγ secretion by single ce


Abstract:

Insight into the behavior of individual immune cells, in particular cytokine secretion, will contribute to a more fundamental understanding of the immune system. In this work, we have developed a cell membrane-anchored sensor for the detection of cytokines secreted by single cells using a combination of aptamer-based sensors and droplet microfluidics.

Liping Qiu,ab Florian Wimmers,b Jorieke Weiden,b Hans A. Heus,c Jurjen Tel*bde and Carl G. Figdor*b Author affiliations * Corresponding authors a Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China b Department of Tumor Immunology, Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands E-mail: Carl.Figdor@radboudumc.nl c Institute for Molecules and Materials, Radboud University, Nijmegen, The Netherlands d Department of Biomedical Engineering, Laboratory of Immunoengineering, Eindhoven University of Technology, Eindhoven, The Netherlands E-mail: J.Tel@tue.nl e Institute for Complex Molecular Systems, Eindhoven University of Technology, Eindhoven, The Netherlands

Link: http://pubs.rsc.org/en/content/articlelanding/2017/cc/c7cc03576d#!divAbstract

#07072017 #membrane #singlecell #sensor

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