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[Review of Scientific Instruments] Controllable picoliter pipetting using hydrophobic microfluidic v


A picoliter pipetting technique using the microfluidic method is presented. Utilizing the hydrophobic self-assembled monolayer films patterned in microchannels as pressure-controlled valves, a small volume of liquid can be separated by a designed channel trap and then ejected from the channel end at a higher pressure. The liquid trap section is composed of a T-shaped channel junction and a hydrophobic patch. The liquid volume can be precisely controlled by varying the distance of the hydrophobic patch from the T-junction. By this means, liquid less than 100 pl can be separated and pipetted. The developed device is potentially useful for sample dispensing in biological, medical, and chemical applications.

M. Zhang1,a), J. Huang1, X. Qian1, S. Mi1, and X. Wang1,2,a)Hide Affiliations 1Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China 2Tsinghua Berkeley Shenzhen Institute, Tsinghua University, Shenzhen 518055, China a)Authors to whom correspondence should be addressed: zhang.min@sz.tsinghua.edu.cn and wang.xiaohao@sz.

Review of Scientific Instruments 88, 065001 (2017); doi: http://dx.doi.org/10.1063/1.4984126

Link: http://aip.scitation.org/doi/10.1063/1.4984126

#07042017 #Valvebasedmicrofluidics #microchannels

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