[ChemPhysChem] Convection-Diffusion Layer in an "Open Space" for Local Surface Treatment a
A four-aperture micro chemical pen was used to produce a stable convection-diffusion layer in an "open space" for micro-reaction and microfabrication. The process represents a new method for micro-reactions and microfabrication in a convection-diffusion layer. To prove the concept of convection-diffusion layer in an "open space", bovine serum albumin (BSA) was labeled with 4-Fluoro-7-nitro-2,1,3-benzoxadiazole (NBD-F) to confirm that the small convection-diffusion layer was effective for local surface treatment. To demonstrate the potential for microfabrication, silver patterns were fabricated on a glass surface via a convection-diffusion layer using the silver mirror reaction. The widths of each silver pattern could be easily controlled from 10 to 60 µm. Patterned silver lines with uniform widths or gradient widths were succeed. This is the first proof of concept study of a convection-diffusion layer in an "open space" use in local surface treatment and microfabrication on a surface. The micro chemical pen represents a potential method for the region-selective micro treatment of tissues, cells and other biological interfaces.
Sifeng Mao, Yong Zhang, Weifei Zhang, Hulie Zeng, Hizuru Nakajima, Jin-Ming Lin, Katsumi Uchiyama Accepted manuscript online: 27 June 2017 DOI: 10.1002/cphc.201700577