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[Angewandte Chemie] Material-Efficient Microfluidic Platform for Exploratory Studies of Visible-Ligh


Abstract:

We present an automated microfluidic platform for in-flow studies of visible-light photoredox catalysis in liquid or gas-liquid reactions at the 15 μL scale. An oscillatory flow strategy enables flexible residence time while preserving the mixing and heat transfer advantages of flow systems. The adjustable photon flux possible with the platform is characterized using actinometry. Case studies of oxidative hydroxylation of phenylboronic acids and dimerization of thiophenol demonstrate the capabilities and advantages of the system. Reaction conditions identified through droplet screening translate directly to continuous synthesis with minor platform modifications.

Connor W Coley, Milad Abolhasani, Hongkun Lin, Klavs F. Jensen Accepted manuscript online: 26 June 2017 DOI: 10.1002/anie.201705148

Link: http://onlinelibrary.wiley.com/doi/10.1002/anie.201705148/abstract?systemMessage=Wiley+Online+Library+will+be+unavailable+on+Saturday+01st+July+from+03.00-09.00+EDT+and+on+Sunday+2nd+July+03.00-06.00+EDT+for+essential+maintenance.++Apologies+for+the+inconvenience.

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