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[Biomicrofluidics] Automatic optimization of drug cocktails on an integrated microfluidic system


Abstract:

Drug cocktails have been popular for a variety of therapies of complicated diseases. Nevertheless, it is a tediously challenging task to optimize formulations, especially using traditional methods. Hence, an automatic system capable of precise dispensing multiple drugs is of great need. Herein, a new integrated microfluidic system combined with a two-axis traverse module was developed to dispense and mix a small amount of drug combination precisely and automatically. This on-chip dispensing process could be performed with a precise and accurate manner when compared to the manual operations. The efficacy of both single and multiple drugs could be examined through the developed microfluidic system with extremely low variation of drug formulations. Analysis of cell viabilities for normal and tumor cells was also performed to verify potential drug combinations. It is envisioned that this automatic system, which is flexible to combine with standard cell analysis methods and novel drug formulation algorithm, could provide precise and high-throughput drug cocktail formulations and expedite the drug screening processes.

Wen-Yen Huang1, Ching-An Liu2, Rong-Syuan Fan1, Zhi-Da Lin1, Kuan Wang2,3,a), and Gwo-Bin Lee1,4,5,a)lessHide Affiliations 1Department of Power Mechanical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan 2Graduate Institute of Nanomedicine and Medical Engineering, Taipei Medical School, Taipei 11031, Taiwan 3College of Biomedical Engineering, Taipei Medical School, Taipei 11031, Taiwan 4Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 30013, Taiwan 5Institute of NanoEngineering and Microsystems, National Tsing Hua University, Hsinchu 30013, Taiwan a)Authors to whom correspondence should be addressed. Electronic addresses: wangk007@gmail.com, Tel.: +886-2-2736-1661, Ext. 7656 and gwobin@pme.nthu.edu.tw, Fax: +886-3-5742495, Tel.: +886-3-5715131 Ext. 33765.

Note: The preliminary results in this paper have been presented at the 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS 2016 Conference, Dublin, Ireland, October 9–13, 2016.

Biomicrofluidics 11, 034109 (2017); doi: http://dx.doi.org/10.1063/1.4983614

Link: http://aip.scitation.org/doi/abs/10.1063/1.4983614

#06192017 #drug #integrated

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