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[Biomicrofluidics] An intra-droplet particle switch for droplet microfluidics using bulk acoustic wa


To transfer cell- and bead-assays into droplet-based platforms typically requires the use of complex microfluidic circuits, which calls for methods to switch the direction of the encapsulated particles. We present a microfluidic chip where the combination of acoustic manipulation at two different harmonics and a trident-shaped droplet-splitter enables direction-switching of microbeads and yeast cells in droplet microfluidic circuits. At the first harmonic, the encapsulated particles exit the splitter in the center daughter droplets, while at the second harmonic, the particles exit in the side daughter droplets. This method holds promises for droplet-based assays where particle-positioning needs to be selectively controlled.

Anna Fornell1,a), Mathias Ohlin2, Fabio Garofalo1, Johan Nilsson1, and Maria Tenje1,2,3Hide Affiliations 1Department Biomedical Engineering, Lund University, Lund, Sweden 2Department Engineering Sciences, Uppsala University, Uppsala, Sweden 3Science for Life Laboratory, Uppsala University, Uppsala, Sweden a)Author to whom correspondence should be addressed: anna.fornell@bme.lth.se

Biomicrofluidics 11, 031101 (2017); doi: http://dx.doi.org/10.1063/1.4984131

Link: http://aip.scitation.org/doi/abs/10.1063/1.4984131?ai=1gvoi&mi=3ricys&af=R

#06082017 #acoustic #MEMS #dropbasedmicrofluidics

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