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[Advanced Materials] Biphasic Supramolecular Self-Assembly of Ferric Ions and Tannic Acid across Int


Abstract:

Cell nanoencapsulation provides a chemical tool for the isolation and protection of living cells from harmful, and often lethal, external environments. Although several strategies are available to form nanometric films, most methods heavily rely on time-consuming multistep processes and are not biocompatible. Here, the interfacial supramolecular self-assembly and film formation of ferric ions (FeIII) and tannic acid (TA) in biphasic systems is reported, where FeIII and TA come into contact each other and self-assemble across the interface of two immiscible phases. The interfacial nanofilm formation developed is simple, fast, and cytocompatible. Its versatility is demonstrated with various biphasic systems: hollow microcapsules, encasing microbial or mammalian cells, that are generated at the water–oil interface in a microfluidic device; a cytoprotective FeIII–TA shell that forms on the surface of the alginate microbead, which then entraps probiotic Lactobacillus acidophilus; and a pericellular FeIII–TA shell that forms on individual Saccharomyces cerevisiae. This biphasic interfacial reaction system provides a simple but versatile structural motif in materials science, as well as advancing chemical manipulability of living cells.

Beom Jin Kim, Sol Han, Kyung-Bok Lee, Insung S. Choi First published: 19 May 2017 DOI: 10.1002/adma.201700784

Link: http://onlinelibrary.wiley.com/doi/10.1002/adma.201700784/abstract

#05222017 #nanofilm #cell #labonachip

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