[Biomicrofluidics] Maximizing particle concentration in deterministic lateral displacement arrays
We present an improvement to deterministic lateral displacement arrays, which allows higher particle concentration enhancement. We correct and extend previous equations to a mirror-symmetric boundary. This approach allows particles to be concentrated into a central channel, no wider than the surrounding gaps, thereby maximizing the particle enrichment. The resulting flow patterns were, for the first time, experimentally measured. The performance of the device with hard micro-spheres and cells was investigated. The observed flow patterns show important differences from our model and from an ideal pattern. The 18 μm gap device showed 11-fold enrichment of 7 μm particles and nearly perfect enrichment—of more than 50-fold—for 10 μm particles and Jurkat cells. This work shows a clear path to achieve higher-than-ever particle concentration enhancement in a deterministic microfluidic separation system.
Shilun Feng1,4, Alison M. Skelley2, Ayad G. Anwer3,4, Guozhen Liu3,4, and David W. Inglis1,4Hide Affiliations 1Department of Engineering, Macquarie University, Sydney, NSW 2109, Australia 2GPB Scientific LLC, 800 East Leigh St., Richmond, Virginia 23219, USA 3Department of Physics and Astronomy, Macquarie University, Sydney, NSW 2109, Australia 4ARC Centre of Excellence for Nanoscale BioPhotonics, Macquarie University, Sydney, NSW 2109, Australia