[ACS Appl. Mater. Interfaces] Mild and Selective C–H Activation of COC Microfluidic Channels Allowin
Plastics, such as cyclic olefin copolymer (COC), are becoming an increasingly popular material for microfluidics. COC is used, in part, because of its (bio)-chemical resistance. However, its inertness and hydrophobicity can be a major downside for many bioapplications. In this paper, we show the first example of a surface-bound selective C–H activation of COC into alcohol C–OH moieties under mild aqueous conditions at room temperature. The nucleophilic COC–OH surface allows for subsequent covalent attachments, such as of a H-terminated silane. The resulting hybrid material (COC–Si-H) was then modified via a photolithographic hydrosilylation in the presence of ω-functionalized 1-alkenes to form a new highly stable, solvent-resistant hybrid surface.
Rui Rijo Carvalho†‡, Sidharam P. Pujari† , Elwin X. Vrouwe‡, and Han Zuilhof*†§∥ † Laboratory of Organic Chemistry, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands ‡ Micronit Microtechnologies B.V., Colosseum 15, 7521 PV Enschede, The Netherlands § School of Pharmaceutical Sciences and Technology, Tianjin University, 92 Weijin Road, Tianjin 300072, P.R. China ∥ Department of Chemical and Materials Engineering, King Abdulaziz University, Jeddah 23218, Saudi Arabia ACS Appl. Mater. Interfaces, Article ASAP DOI: 10.1021/acsami.7b02022 Publication Date (Web): May 8, 2017 Copyright © 2017 American Chemical Society *E-mail: firstname.lastname@example.org.