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[ACS Appl. Mater. Interfaces] Mild and Selective C–H Activation of COC Microfluidic Channels Allowin


Abstract:

Plastics, such as cyclic olefin copolymer (COC), are becoming an increasingly popular material for microfluidics. COC is used, in part, because of its (bio)-chemical resistance. However, its inertness and hydrophobicity can be a major downside for many bioapplications. In this paper, we show the first example of a surface-bound selective C–H activation of COC into alcohol C–OH moieties under mild aqueous conditions at room temperature. The nucleophilic COC–OH surface allows for subsequent covalent attachments, such as of a H-terminated silane. The resulting hybrid material (COC–Si-H) was then modified via a photolithographic hydrosilylation in the presence of ω-functionalized 1-alkenes to form a new highly stable, solvent-resistant hybrid surface.

Rui Rijo Carvalho†‡, Sidharam P. Pujari† , Elwin X. Vrouwe‡, and Han Zuilhof*†§∥ † Laboratory of Organic Chemistry, Wageningen University & Research, Stippeneng 4, 6708 WE Wageningen, The Netherlands ‡ Micronit Microtechnologies B.V., Colosseum 15, 7521 PV Enschede, The Netherlands § School of Pharmaceutical Sciences and Technology, Tianjin University, 92 Weijin Road, Tianjin 300072, P.R. China ∥ Department of Chemical and Materials Engineering, King Abdulaziz University, Jeddah 23218, Saudi Arabia ACS Appl. Mater. Interfaces, Article ASAP DOI: 10.1021/acsami.7b02022 Publication Date (Web): May 8, 2017 Copyright © 2017 American Chemical Society *E-mail: han.zuilhof@wur.nl.

Link: http://pubs.acs.org/doi/abs/10.1021/acsami.7b02022

#05162017 #MaterialScience #microchannels

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