[Analytical Chemistry] Liquid beam desorption mass spectrometry for the investigation of continuous
In this work we present the combination of microfluidic chips and mass spectrometry employing laser-induced liquid beam ionisation/desorption. The developed system was evaluated with respect to stable beam generation, laser parameters as well as solvent compatibility. The device was exemplarily applied to study a vinylogous Mannich reaction peformed in continu-ous flow on chip. Fast processes can be observed with this technique which could in future be beneficial for studying inter-mediates or contribute to the elucidation of reaction mechanisms.
Sandra Schulze, Maik Pahl, Ferdinand Stolz, Johannes Appun, Bernd Abel, Christoph Schneider, and Detlev Belder
Anal. Chem., Just Accepted Manuscript
Publication Date (Web): May 10, 2017
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