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[Analytical Chemistry] Liquid beam desorption mass spectrometry for the investigation of continuous


In this work we present the combination of microfluidic chips and mass spectrometry employing laser-induced liquid beam ionisation/desorption. The developed system was evaluated with respect to stable beam generation, laser parameters as well as solvent compatibility. The device was exemplarily applied to study a vinylogous Mannich reaction peformed in continu-ous flow on chip. Fast processes can be observed with this technique which could in future be beneficial for studying inter-mediates or contribute to the elucidation of reaction mechanisms.

Sandra Schulze, Maik Pahl, Ferdinand Stolz, Johannes Appun, Bernd Abel, Christoph Schneider, and Detlev Belder

Anal. Chem., Just Accepted Manuscript

DOI: 10.1021/acs.analchem.7b01026

Publication Date (Web): May 10, 2017

Copyright © 2017 American Chemical Society

Link: http://pubs.acs.org/doi/abs/10.1021/acs.analchem.7b01026

#05132017 #massspectrometry #labonachip

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