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[Chemical Communications] Synthesis of new hydrophilic rhodamine based enzymatic substrates compatib


Abstract:

Here we report the conception, synthesis and evaluation of new hydrophilic rhodamine-based enzymatic substrates for detection of peptidase activity compatible with high-throughput screening using droplet-based microfluidics.

Johan Fenneteau,a Dany Chauvin,b Andrew D. Griffiths,b Clément Nizak*b and Janine Cossy*a Author affiliations * Corresponding authors a Laboratoire de Chimie Organique, Institute of Chemistry, Biology and Innovation (CBI), UMR 8231, ESPCI Paris/CNRS, PSL Research University, 10 rue Vauquelin, 75231-Paris Cedex 05, France E-mail: janine.cossy@espci.fr b Laboratoire de Biochimie, Institute of Chemistry, Biology and Innovation (CBI), UMR 8231, ESPCI Paris/CNRS, PSL Research University, 10 rue Vauquelin, 75231-Paris Cedex 05, France E-mail: clement.nizak@espci.fr

Link: http://pubs.rsc.org/en/Content/ArticleLanding/2017/CC/C7CC01506B#!divAbstract

#05042017 #chemistry #dropbasedmicrofluidics #enzyme #hydrophilic

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