[Patent] COMPARTMENTALISED SCREENING BY MICROFLUIDIC CONTROL
The invention describes a method for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, comprising the steps of: a) compartmentalising the compounds into microcapsules together with the target, such that only a subset of the repertoire is represented in multiple copies in any one microcapsule; and b) identifying the compound which binds to or modulates the activity of the target; wherein at least one step is performed under microfluidic control. The invention enables the screening of large repertoires of molecules which can serve as leads for drug development.
Document Type and Number: United States Patent Application 20170102381 Kind Code: A1
Inventors: Griffiths, Andrew David (Strasbourg, FR) Weitz, David A. (Cambridge, MA, US) Link, Darren Roy (Lexington, MA, US) Ahn, Keunho (Boston, MA, US) Bibette, Jerome (Paris, FR) Application Number: 15/331445 Publication Date: 04/13/2017 Filing Date: 10/21/2016