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[Trends in Biotechnology] Multiplexed Point-of-Care Testing – xPOCT


Multiplexed point-of-care testing (xPOCT), which is simultaneous on-site detection of different analytes from a single specimen, has recently gained increasing importance for clinical diagnostics, with emerging applications in resource-limited settings (such as in the developing world, in doctors’ offices, or directly at home). Nevertheless, only single-analyte approaches are typically considered as the major paradigm in many reviews of point-of-care testing. Here, we comprehensively review the present diagnostic systems and techniques for xPOCT applications. Different multiplexing technologies (e.g., bead- or array-based systems) are considered along with their detection methods (e.g., electrochemical or optical). We also address the unmet needs and challenges of xPOCT. Finally, we critically summarize the in-field applicability and the future perspectives of the presented approaches.

Can Dincer, Richard Bruch, André Kling, Petra S. Dittrich, Gerald A. Urban @Twitter: @ImtekSensors Published Online: April 26, 2017 Publication stage: In Press Corrected Proof Open Access DOI: http://dx.doi.org/10.1016/j.tibtech.2017.03.013

Link: http://www.cell.com/trends/biotechnology/fulltext/S0167-7799(17)30062-8?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0167779917300628%3Fshowall%3Dtrue

#05022017 #pointofcare #detection #array #analyte #diagnostics #Biologicalapplication #electrochemical #optical

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