[Trends in Biotechnology] Multiplexed Point-of-Care Testing – xPOCT
Multiplexed point-of-care testing (xPOCT), which is simultaneous on-site detection of different analytes from a single specimen, has recently gained increasing importance for clinical diagnostics, with emerging applications in resource-limited settings (such as in the developing world, in doctors’ offices, or directly at home). Nevertheless, only single-analyte approaches are typically considered as the major paradigm in many reviews of point-of-care testing. Here, we comprehensively review the present diagnostic systems and techniques for xPOCT applications. Different multiplexing technologies (e.g., bead- or array-based systems) are considered along with their detection methods (e.g., electrochemical or optical). We also address the unmet needs and challenges of xPOCT. Finally, we critically summarize the in-field applicability and the future perspectives of the presented approaches.
Can Dincer, Richard Bruch, André Kling, Petra S. Dittrich, Gerald A. Urban @Twitter: @ImtekSensors Published Online: April 26, 2017 Publication stage: In Press Corrected Proof Open Access DOI: http://dx.doi.org/10.1016/j.tibtech.2017.03.013