• Microfluidics News Admin

[eLife] Nonlinear feedback drives homeostatic plasticity in H2O2 stress response


Homeostatic systems that rely on genetic regulatory networks are intrinsically limited by the transcriptional response time, which may restrict a cell’s ability to adapt to unanticipated environmental challenges. To bypass this limitation, cells have evolved mechanisms whereby exposure to mild stress increases their resistance to subsequent threats. However, the mechanisms responsible for such adaptive homeostasis remain largely unknown. Here, we used live-cell imaging and microfluidics to investigate the adaptive response of budding yeast to temporally controlled H2O2stress patterns. We demonstrate that acquisition of tolerance is a systems-level property resulting from nonlinearity of H2O2 scavenging by peroxiredoxins and our study reveals that this regulatory scheme induces a striking hormetic effect of extracellular H2O2 stress on replicative longevity. Our study thus provides a novel quantitative framework bridging the molecular architecture of a cellular homeostatic system to the emergence of nonintuitive adaptive properties.

Youlian Goulev Sandrine Morlot Audrey Matifas Bo Huang Mikael Molin Michel B Toledano Gilles Charvin Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, Université de Strasbourg, France; IBITECS, SBIGEM, CEA-Saclay, France; University of Gothenburg, Sweden DOI: http://dx.doi.org/10.7554/eLife.23971 Published April 18, 2017 Cite as eLife 2017;10.7554/eLife.23971

Link: https://elifesciences.org/content/6/e23971

#04202017 #stress #homeostatic #plasticity

5 views0 comments

Recent Posts

See All

© 2017 by "Microfluidics News".