[Analytical Chemistry] Beyond Wicking: Expanding the Role of Patterned Paper as the Foundation for a
This Feature article discusses the use of patterned paper as a platform for the development of low-cost microfluidic devices and analytical tests that are designed for use in limited-resource settings. While a number of assays for soluble analytes have been developed using paper-based microfluidic devices, the detection and analysis of blood cells has remained an outstanding challenge. Expanding the utility of paper to determine cell counts would address a critical disparity that exists in managing healthcare and diagnosing diseases at the point-of-care. To realize this capability, an improved understanding of the relationship between paper and blood cells is required. In this Feature, we highlight the different material properties of paper and how they contribute to the development and performance of paper-based microfluidic devices. Finally, we discuss how, by considering all of these properties, paper-based devices can be designed to enable cellular assays for use at the point-of-care.
Syrena C. Fernandes, Jenna A Walz, Daniel J Wilson, Jessica C. Brooks, and Charles R. Mace Anal. Chem., Just Accepted Manuscript DOI: 10.1021/acs.analchem.6b03860 Publication Date (Web): April 13, 2017 Copyright © 2017 American Chemical Society