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[Angewandte Chemie] Online Flowing Colloidosomes for Sequential Multi-Analyte High-Throughput SERS A


3D plasmonic colloidosomes are superior SERS sensors owing to their high sensitivity and excellent tolerance to laser misalignment. Herein, we incorporate plasmonic colloidosomes in a microfluidic channel for online SERS detection. Our method resolves the poor signal reproducibility and inter-sample contamination in the existing online SERS platforms. Our flow system offers rapid and continuous online detection of 20 samples in less than 5 min with excellent signal reproducibility. The isolated colloidosomes prevent cross-sample and channel contamination, allowing accurate quantification of samples over a concentration range of five orders of magnitude. Our system demonstrates high-resolution multiplex detection with fully preserved signal and Raman features of individual analytes in a mixture. High-throughput multi-assay analysis is performed, which highlights that our system is capable of rapid identification and quantification of a sequence of samples containing various analytes and concentrations.

Gia Chuong Phan-Quang, Elizabeth Hui Zi Wee, Fengling Yang, Hiang Kwee Lee, Dr. In Yee Phang, Xiaotong Feng, Prof. Ramón A. Alvarez-Puebla, Prof. Xing Yi Ling First published: 11 April 2017Full publication history DOI: 10.1002/anie.201702374

Link: http://onlinelibrary.wiley.com/doi/10.1002/anie.201702374/abstract?systemMessage=Pay+Per+View+on+Wiley+Online+Library+will+be+unavailable+on+Saturday+15th+April+from+12%3A00-09%3A00+EDT+for+essential+maintenance.++Apologies+for+the+inconvenience.

#04122017 #chemistry #SERS #detection #raman

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