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[Scientific Report] Functionalized core-shell hydrogel microsprings by anisotropic gelation with bev


Abstract:

This study describes a novel microfluidic-based method for the synthesis of hydrogel microsprings that are capable of encapsulating various functional materials. A continuous flow of alginate pre-gel solution can spontaneously form a hydrogel microspring by anisotropic gelation around the bevel-tip of the capillary. This technique allows fabrication of hydrogel microsprings using only simple capillaries and syringe pumps, while their complex compartmentalization characterized by a laminar flow inside the capillary can contribute to the optimization of the microspring internal structure and functionality. Encapsulation of several functional materials including magnetic-responsive nanoparticles or cell dispersed collagen for tissue scaffold was demonstrated to functionalize the microsprings. Our core-shell hydrogel microsprings have immense potential for application in a number of fields, including biological/chemical microsensors, biocompatible soft robots/microactuators, drug release, self-assembly of 3D structures and tissue engineering.

Koki Yoshida & Hiroaki Onoe Scientific Reports 7, Article number: 45987 (2017) doi:10.1038/srep45987

Link: http://www.nature.com/articles/srep45987

#04062017 #core #shell #gel #capillary #microspring #microsensor #microactuator #drugrelease #Selfassembly #tissueengineering

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