[Annual Review of Analytical Chemistry] Light-Addressable Potentiometric Sensors for Quantitative Sp
A light-addressable potentiometric sensor (LAPS) is a semiconductor-based chemical sensor, in which a measurement site on the sensing surface is defined by illumination. This light addressability can be applied to visualize the spatial distribution of pH or the concentration of a specific chemical species, with potential applications in the fields of chemistry, materials science, biology, and medicine. In this review, the features of this chemical imaging sensor technology are compared with those of other technologies. Instrumentation, principles of operation, and various measurement modes of chemical imaging sensor systems are described. The review discusses and summarizes state-of-the-art technologies, especially with regard to the spatial resolution and measurement speed; for example, a high spatial resolution in a submicron range and a readout speed in the range of several tens of thousands of pixels per second have been achieved with the LAPS. The possibility of combining this technology with microfluidic devices and other potential future developments are discussed.
Annual Review of Analytical Chemistry Vol. 10:- (Volume publication date July 2017) Review in Advance first posted online on March 27, 2017. (Changes may still occur before final publication.) DOI: 10.1146/annurev-anchem-061516-045158 Tatsuo Yoshinobu,1,2 Ko-ichiro Miyamoto,2 Carl Frederik Werner,2 Arshak Poghossian,3,4 Torsten Wagner,3,4 and Michael J. Schöning3,4 1Department of Biomedical Engineering, Tohoku University, Sendai, 980-8579, Japan; email: firstname.lastname@example.org 2Department of Electronic Engineering, Tohoku University, Sendai 980–8579, Japan 3Institute of Nano- and Biotechnologies, Aachen University of Applied Sciences, Jülich Campus, Jülich 52428, Germany 4Peter Grünberg Institute, Research Centre Jülich GmbH, Jülich 52425, Germany