[Annual Review of Analytical Chemistry] Chemical and Biological Dynamics Using Droplet-Based Microfl
Recent years have witnessed an increased use of droplet-based microfluidic techniques in a wide variety of chemical and biological assays. Nevertheless, obtaining dynamic data from these platforms has remained challenging, as this often requires reading the same droplets (possibly thousands of them) multiple times over a wide range of intervals (from milliseconds to hours). In this review, we introduce the elemental techniques for the formation and manipulation of microfluidic droplets, together with the most recent developments in these areas. We then discuss a wide range of analytical methods that have been successfully adapted for analyte detection in droplets. Finally, we highlight a diversity of studies where droplet-based microfluidic strategies have enabled the characterization of dynamic systems that would otherwise have remained unexplorable.
Annual Review of Analytical Chemistry Vol. 10:- (Volume publication date July 2017) Review in Advance first posted online on March 24, 2017. (Changes may still occur before final publication.) DOI: 10.1146/annurev-anchem-061516-045219 Oliver Dressler, Xavier Casadevall i Solvas, and Andrew J. deMello Department of Chemistry and Applied Biosciences, ETH Zürich, Switzerland; email: firstname.lastname@example.org