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[Macromolecular Chemistry and Physics] Hollow Microcapsules with Enhanced Stability via Stereocomple


This paper presents a microfluidic approach for fabricating stereocomplexed hollow microcapsules that uses water-in-oil-in-water double-emulsion droplets as templates. The polylactides functionalized with 2-ureido-4[1H]-pyrimidinone (UPy) end groups are intermolecularly stereocomplexed by polylactides with opposite configurations to promote their self-assembly at a water-chloroform interface. This intermolecular interaction can significantly enhance the stability of resulting hollow microcapsules so that they preserve their shape and size after drying. Moreover, because these stimuli-responsive polylactides can assemble and disassemble into superstructures, they can be made to release their cargo by varying the pH values. The interfacially assembled supramolecular microcapsules, which possess stimuli-responsiveness and long-term stability, are potentially useful for encapsulation and delivery of drugs.

Marek Brzeziński First published: 31 March 2017 DOI: 10.1002/macp.201700018

Link: http://onlinelibrary.wiley.com/doi/10.1002/macp.201700018/full

#04052017 #microcapsule #MaterialScience #DrugDelivery

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