[J. Funct. Biomater.] Endovascular Embolization by Transcatheter Delivery of Particles: Past, Presen
Minimally invasive techniques to occlude flow within blood vessels, initially pioneered in the 1970s with autologous materials and subsequently advanced with increasingly sophisticated engineered biomaterials, are routinely performed for a variety of medical conditions. Contemporary interventional radiologists have at their disposal a wide armamentarium of occlusive agents to treat a range of disease processes through a small incision in the skin. In this review, we provide a historical perspective on endovascular embolization tools, summarize the current state-of-the-art, and highlight burgeoning technologies that promise to advance the field in the near future.
Rahul A. Sheth 1, Sharjeel Sabir 1, Savitri Krishnamurthy 2, Reginald K. Avery 3,4, Yu Shrike Zhang 3,4, Ali Khademhosseini 3,4 and Rahmi Oklu 4,5,* 1 Department of Interventional Radiology, Division of Diagnostic Imaging, MD Anderson Cancer Center, Houston, TX 77030, USA 2 Department of Pathology, MD Anderson Cancer Center, Houston, TX 77030, USA 3 Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA 4 Biomaterials Innovation Research Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02139, USA 5 Division of Interventional Radiology, Mayo Clinic, 5777 E Mayo Blvd, Scottsdale AZ 85054, USA * Author to whom correspondence should be addressed. Academic Editor: Francesco Cilurzo Received: 16 November 2016 / Revised: 11 March 2017 / Accepted: 28 March 2017 / Published: 3 April 2017