[ACS Appl. Mater. Interfaces] Regulation of drug release by tuning surface textures of biodegradable
Generally, size, uniformity, shape and surface chemistry of the biodegradable polymer particles will significantly influence in drug release behavior in vitro and in vivo. In this paper, uniform poly(D, L-lactic-co-glycolide) (PLGA) and PLGA-b-poly(ethylene glycol) (PLGA-b-PEG) microparticles with tunable surface textures were generated by taking advantage of interfacial instabilities of emulsion droplet and polymer blending strategy. Monodisperse emulsion droplets containing polymers were generated through microfluidic technique, and removal of organic solvent from the droplets will trigger the interfacial instabilities (spontaneous increase in interfacial area), leading to the formation of uniform polymer particles with textured surfaces. With the introduction of homopolymer PLGA into PLGA-b-PEG, hydrophobicity of the polymer systems can be tailored and qualitatively different interfacial behavior of the emulsion droplets during solvent removal was observed. Uniform polymer particles with tunable surface roughness can thus be generated by changing the ratio of PLGA to PLGA-b-PEG. More interestingly, surface textures on the particles determined drug loading efficiency and release kinetics of the encapsulated hydrophobic paclitaxel (PTX), which follows diffusion-directed drug release pattern. The polymer particles with different surface textures demonstrate good cell viability and biocompatibility, indicating the promising role of the particles in the fields of drug or gene delivery for tumor therapy, vaccine, biodiagnostics, and bioimaging.
Mubashir Hussain, Jun Xie, Zaiyan Hou, Khurram Shezad, Jiangping Xu, Ke Wang, Yujie Gao, Lei Shen, and Jintao Zhu ACS Appl. Mater. Interfaces, Just Accepted Manuscript DOI: 10.1021/acsami.7b02002 Publication Date (Web): April 3, 2017 Copyright © 2017 American Chemical Society