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[NANOMED Conference] 3d printing stereo networks microfluidic concentration gradient chip


Abstract:

As a new technology platform, the microfluidic concentration gradient chip (CGC) has recently attracted a large amount of interest in the field of biomedical engineering such as drug screening, chemical synthesis, trend research, cell apoptosis etc. In this work, a 4-inlet, 36-outlet stereo networks microfluidic CGC was brought forward and fabricated by 3D printing technology. Numerical simulations for the fluid flow in the network have been performed and different curves of CGC distribution can be obtained, including linear, parabola, and periodic gradients. Experiment results proved that such stereo network architectures could successfully form the desired concentration gradient and it has the merits of multiple analytes, good ductility, good readability, high-throughput, and so on, offers a unique platform to characterize various drug screening in a high-throughput fashion. Published in: Nano/Molecular Medicine and Engineering (NANOMED), 2016 IEEE 10th International Conference on Date of Conference: 30 Oct.-2 Nov. 2016 Date Added to IEEE Xplore: 30 March 2017 ISBN Information: Electronic ISSN: 2159-6972 DOI: 10.1109/NANOMED.2016.7883575 Publisher: IEEE

Xiaojun Chen Department of Mechanical & Electrical Engineering, Xiamen University Room 339, Science Building, Xiamen University, Xiamen 361005, China Dezhi Wu Department of Mechanical & Electrical Engineering, Xiamen University Room 339, Science Building, Xiamen University, Xiamen 361005, China Xuecui Mei Department of Mechanical & Electrical Engineering, Xiamen University Room 339, Science Building, Xiamen University, Xiamen 361005, China Zhou Zhou Department of Mechanical & Electrical Engineering, Xiamen University Room 339, Science Building, Xiamen University, Xiamen 361005, China Lingyun Wang Department of Mechanical & Electrical Engineering, Xiamen University Room 339, Science Building, Xiamen University, Xiamen 361005, China Yang Zhao Department of Mechanical & Electrical Engineering, Xiamen University Room 339, Science Building, Xiamen University, Xiamen 361005, China Gaofeng Zheng Department of Mechanical & Electrical Engineering, Xiamen University Room 339, Science Building, Xiamen University, Xiamen 361005, China Daoheng Sun Department of Mechanical & Electrical Engineering, Xiamen University Room 339, Science Building, Xiamen University, Xiamen 361005, China

Link: http://ieeexplore.ieee.org/abstract/document/7883575/

#04032017 #3dprinting #gradient #CGC #simulation

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