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[Microfluidics and Nanofluidics] Hybrid paper-based microfluidics: combination of paper-based analyt


Microfluidics found its place in point of care diagnostics. Microfluidic devices on paper substrate are proposed on both channel-based and digital microfluidics (DMF). But fluid flow controlling on microfluidics paper-based analytical devices (µPADs) and post-processing on DMF devices have limitations. In this work a new hybrid paper-based device is proposed with the aim of resolving these limitations and expanding the microfluidics capabilities in point of care diagnostics. The hybrid paper-based microfluidics (HPMF) device is composed of a DMF device following a µPAD in a single substrate, in which the DMF part performs the preprocessing steps of the test on droplets and transfers the resulting droplet to the µPAD part of the device for post-processing steps. The fabrication process of the device is rapid and very low cost due to use of paper substrate and out of clean-room processes. The results show that the proposed HPMF device can perform droplet operations: moving, mixing, and splitting.

Arash Abadian, Samira Sepehri Manesh, Shahin Jafarabadi Ashtiani Research Paper First Online: 24 March 2017 DOI: 10.1007/s10404-017-1899-2 Cite this article as: Abadian, A., Sepehri Manesh, S. & Jafarabadi Ashtiani, S. Microfluid Nanofluid (2017) 21: 65. doi:10.1007/s10404-017-1899-2

Link: https://link.springer.com/article/10.1007/s10404-017-1899-2

#03302017 #hybrid #paperbasedmicrofluidics #uPAD #DMF #MEMS #digitalmicrofluidics #pointofcare

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