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[Sensors and Actuators B: Chemical] Mitigating positional dependence in coplanar electrode Coulter-t


Microfluidic impedance-based devices with coplanar electrode layout represent an attractive tool for low-cost, label-free, single-cell analysis. However, their usefulness has long been limited by the positional dependence of the measured signals, i.e., identical particles traveling along different paths provide different traces. In this paper we show that it is possible to significantly reduce this unwanted effect via straightforward signal processing, by exploiting the richness of the information contained in the recorded traces.

Vito Errico a, 1, Adele De Ninno a, 1, Francesca Romana Bertani b, Luca Businaro b, Paolo Bisegna a, Federica Caselli a,

a Department of Civil Engineering and Computer Science, University of Rome Tor Vergata, 00133 Rome, Italy

b Institute for Photonics and Nanotechnologies, Italian National Research Council, 00156 Rome, Italy

Received 11 December 2016, Revised 16 February 2017, Accepted 8 March 2017, Available online 12 March 2017


Link: http://www.sciencedirect.com/science/article/pii/S0925400517304525

#03172017 #labelfree #Biologicalapplication #electrode #signal #singlecell #MEMS

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