[Annual Review of Analytical Chemistry] Coupling Front-End Separations, Ion Mobility Spectrometry, a
Ion mobility spectrometry (IMS) is a widely used analytical technique for rapid molecular separations in the gas phase. Though IMS alone is useful, its coupling with mass spectrometry (MS) and front-end separations is extremely beneficial for increasing measurement sensitivity, peak capacity of complex mixtures, and the scope of molecular information available from biological and environmental sample analyses. In fact, multiple disease screening and environmental evaluations have illustrated that the IMS-based multidimensional separations extract information that cannot be acquired with each technique individually. This review highlights three-dimensional separations using IMS-MS in conjunction with a range of front-end techniques, such as gas chromatography, supercritical fluid chromatography, liquid chromatography, solid-phase extractions, capillary electrophoresis, field asymmetric ion mobility spectrometry, and microfluidic devices. The origination, current state, various applications, and future capabilities of these multidimensional approaches are described in detail to provide insight into their uses and benefits.
Xueyun Zheng,1 Roza Wojcik,1 Xing Zhang,2 Yehia M. Ibrahim,1 Kristin E. Burnum-Johnson,1 Daniel J. Orton,1Matthew E. Monroe,1 Ronald J. Moore,1 Richard D. Smith,1 and Erin S. Baker1
1Earth and Biological Sciences Directorate, Pacific Northwest National Laboratory, Richland, WA 99352; email: email@example.com
2Skaggs School of Pharmacy and Pharmaceutical Sciences, Anschutz Medical Campus, University of Colorado, Denver, Colorado 80045
Vol. 10:- (Volume publication date July 2017) Review in Advance first posted online on February 23, 2017. (Changes may still occur before final publication.) DOI: 10.1146/annurev-anchem-061516-045212