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[Bioresource Technology] Microfluidic perfusion bioreactor for optimization of microalgal lipid prod


Nutrient deprivation in a batch process induces microbes to produce secondary metabolites while drastically constraining cellular growth. A microfluidic continuous perfusion system was designed and tested to culture microalgae, Chlamydomonas reinhardtii, under constant nutrient concentration slightly lower than normal condition. When cultured in 7.5%/7.5% of NH4+/PO42−, C. reinhardtii showed a 2.4-fold increase in TAG production with a 3.5-fold increase in biomass compared to level obtained under an only NH4+ depleted condition. The microfluidic continuous perfusion bioreactor with steady continuous nutrient flow can be used to optimize conditions for enhancing secondary metabolite production and increasing microbial biomass.

Sang-Min Paik, Sang-Jun Sim, Noo Li Jeon

Bioresource Technology

Link: http://www.sciencedirect.com/science/article/pii/S0960852417301736

#bioreactor #03122017 #microalgal #lipid

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