[Small]Drug Delivery: One-Step Microfluidic Synthesis of Nanocomplex with Tunable Rigidity and Acid-
In article number 1603109, Jiashu Sun, Haijun Yu, Xingyu Jiang, and co-workers utilize microfluidic chips to generate rigid pH-sensitive micellar nanocomplex (RPN) with tunable rigidity and acid-switchable surface charge for overcoming cancer drug resistance. The functionalization of RPN is realized through the incorporation of rigid PLGA core into pH-sensitive micelle. The RPN significantly enhances therapeutic efficacy against MCF-7/ADR xenograft tumor in mice, without the assistance of other therapeutic means.
Qiang Feng, Jianping Liu, Xuanyu Li, Qinghua Chen, Jiashu Sun, Xinghua Shi, Baoquan Ding, Haijun Yu, Yaping Li, Xingyu Jiang