• Microfluidics News Admin

[Conference]Tumor cell isolation in microfluidic devices for cancer treatment monitoring


Abstract:

This paper reports two microfluidic devices for isolating circulating tumor cells (CTCs) in blood samples of pancreatic cancer patients. These devices consist of micromixers or micropillars for enhancing the interactions between tumor cells and capture agents, which are immobilized onto the surfaces of microchannels and microfeatures. Both antibodies and aptamers, as well as their ensemble, have been explored for tumor cell isolation. The devices have been used for enumerating CTCs and we have correlated the CTC number with the anti-cancer treatment responses in a clinical trial.

Conference: Micro Electro Mechanical Systems (MEMS), 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS)

Date of Conference: 22-26 Jan. 2017

Date Added to IEEE Xplore: 28 February 2017

DOI: 10.1109/MEMSYS.2017.7863647

Z. Hugh Fan

University of Florida, Gainesville, FL 32611-6250, USA

Jose I. Varillas

University of Florida, Gainesville, FL 32611-6250, USA

Jinling Zhang

University of Florida, Gainesville, FL 32611-6250, USA

Kangfu Chen

University of Florida, Gainesville, FL 32611-6250, USA

Thomas J. George

University of Florida, Gainesville, FL 32611-6250, USA

Link: http://ieeexplore.ieee.org/abstract/document/7863647/?section=abstract

#tumorcellisolation #cancer #CTC #diagnostics #MEMS #Biologicalapplication

Recent Posts

See All

© 2017 by "Microfluidics News".