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[Conference]Red blood cell deformability upon continuous or repetitive loadings


Abstract:

This paper focuses on the comparison of red blood cell (RBC) deformability under continuous and repetitive loadings. We utilized a feedback position-control system and a narrow microfluidic channel for applying different deformation patterns on RBCs. According to the analyses of shape recoveries with different patterns, we found, for the first time, that the mechanical responses of RBCs upon continuous and repetitive loadings are almost the same within the error among cellular individualities as long as the total duration of the loading is the same. The result indicates that the internal mechanical stress on RBCs accumulates even if the apparent cell shape recovers. The finding provides quantitative insights for the systematic comparison among various exisiting measurement methods of mechanical responses of cells.

Published in: Micro Electro Mechanical Systems (MEMS), 2017 IEEE 30th International Conference on MEMS

Date of Conference: 22-26 Jan. 2017

Date Added to IEEE Xplore: 28 February 2017

DOI: 10.1109/MEMSYS.2017.7863360

Hiroaki Ito

Department of Mechanical Engineering, Osaka University, Osaka, Japan

Ryo Murakami

Department of Mechanical Engineering, Osaka University, Osaka, Japan

Chia-Hung Dylan Tsai

Department of Mechanical Engineering, Osaka University, Osaka, Japan

Mitsuhiro Horade

Department of Mechanical Engineering, Osaka University, Osaka, Japan

Motomu Tanaka

Institute of Physical Chemistry, University of Heidelberg, Heidelberg, Germany

Makoto Kaneko

Department of Mechanical Engineering, Osaka University, Osaka, Japan

Link: http://ieeexplore.ieee.org/abstract/document/7863360/

#MEMS #RedBloodCell #CellularBiophysics

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