Abstract:

A dual-modality microfluidic immunosensor is reported for the detection of cancer biomarker proteins using graphene oxide assembled periodic gold nanoposts array. The sensor uniquely provides both electrochemical and surface plasmon resonance (SPR) signatures on a single platform. Sensitivities for both electrochemical and SPR detection schemes are found to be 3.94 μΑ/μΜ/cm2 in a range of 1×10−15 M to 0.1×10−6M, and 2.9 nm/μM/cm2 in a range of 1×10−15 M to 1×10−9M, respectively, for the detection of epidermal growth factor receptor 2 (ErbB2) breast biomarker. The present dual-modality sensor approach enables improved detection reliability and precision, and reduced false reads.

Published in: Micro Electro Mechanical Systems (MEMS), 2017 IEEE 30th International Conference on MEMS

Date of Conference: 22-26 Jan. 2017

Date Added to IEEE Xplore: 28 February 2017

DOI: 10.1109/MEMSYS.2017.7863423

Md. Azahar Ali

Department of Electrical and Computer Engineering, Iowa State University, Ames, Iowa, USA

Shawana Tabassum

Department of Electrical and Computer Engineering, Iowa State University, Ames, Iowa, USA

Qiugu Wang

Department of Electrical and Computer Engineering, Iowa State University, Ames, Iowa, USA

Yifei Wang

Department of Electrical and Computer Engineering, Iowa State University, Ames, Iowa, USA

Ratnesh Kumar

Department of Electrical and Computer Engineering, Iowa State University, Ames, Iowa, USA

Liang Dong

Department of Electrical and Computer Engineering, Iowa State University, Ames, Iowa, USA

Link: http://ieeexplore.ieee.org/abstract/document/7863423/

#MEMS #sensor #cancer #surfaceplasmonresonance #Biologicalapplication