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[Conference]On-Chip Cell Gym


Abstract:

A novel microfluidic system for applying cyclic pressure to cells during incubation is developed and tested in this work. The cyclic pressure generates stress stimulus to the cells, and is named “Cell Exercise” in this work. The goal of this paper is to design an “On-Chip Cell Gym” where we can observe what happens during the cell exercise in real-time. We design the cell gym on a PDMS chip composed of two parallel chamber arrays, so that we can directly observe the difference with and without Cell Exercise. Cells in one group of chamber is cultured under cell exercise mode and the other one is under none cell exercise mode. Dramatic growth of cell stress fibers is observed in the group of cell exercise with respect to the group without any exercise.

Published in: Micro Electro Mechanical Systems (MEMS), 2017 IEEE 30th International Conference on

Date of Conference: 22-26 Jan. 2017

Date Added to IEEE Xplore: 28 February 2017

DOI: 10.1109/MEMSYS.2017.7863479

Mitsuhiro Horade

Graduate School of Engineering, Osaka University, Japan

Chia-Hung Dylan Tsai

Graduate School of Engineering, Osaka University, Japan

Hiroaki Ito

Graduate School of Engineering, Osaka University, Japan

Nobuya Higashino

Graduate School of Engineering, Osaka University, Japan

Takayuki Akai

Graduate School of Engineering, Osaka University, Japan

Utako Yokoyama

Graduate School of Medicine, Yokohama City University, Japan

Yoshihiro Ishikawa

Graduate School of Medicine, Yokohama City University, Japan

Shinya Sakuma

Graduate School of Engineering, Nagoya University, Japan

Fumihito Arai

Graduate School of Engineering, Nagoya University, Japan

Makoto Kaneko

Graduate School of Engineering, Osaka University, Japan

Link: http://ieeexplore.ieee.org/abstract/document/7863479/

#cyclicpressure #cell #CellularBiophysics

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