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[Conference]Microfluidic chip having multi fluorescence microsensors for spatiotemporal sensing of c


Abstract:

We proposed on-chip spatiotemporal sensing for monitoring interactions between cells and environment using fluorescence multi-microsensors. The microfluidic chip integrating fluorescence multi-microsensor is used to construct the harmonious environment like in vivo to reconstruct high-quality organs ex vivo. Fluorescence sensing is suitable for spatiotemporal sensing with high spatial resolution because wiring to many microsensors limits the number of sensors. First, we classify optical sensing method. Fluorescence and polarization sensing are suitable for spatiotemporal sensing such as physiological and mechanical parameters in culture environment. As a demonstration of spatiotemporal sensing of culture environment, Spatiotemporal variation of pH, Ca2+ was measured and during transformation of octacalcium phosphate (OCP) to hydroxyl apatite (HA) inside the microfluidic chip using fluorescence multi-microsensors.

Published in: Micro Electro Mechanical Systems (MEMS), 2017 IEEE 30th International Conference on MEMS

Date of Conference: 22-26 Jan. 2017

Date Added to IEEE Xplore: 28 February 2017

DOI: 10.1109/MEMSYS.2017.7863422

Hisataka Maruyama

Department of Micro-Nano Systems Engineering, Nagoya University, Nagoya, Japan

Keisuke Takagi

Department of Micro-Nano Systems Engineering, Nagoya University, Nagoya, Japan

Taisuke Masuda

Department of Micro-Nano Systems Engineering, Nagoya University, Nagoya, Japan

Osamu Suzuki

Division of Craniofacial Function Engineering, Tohoku University, Nagoya, Japan

Fumihito Arai

Department of Micro-Nano Systems Engineering, Nagoya University, Nagoya, Japan

Link: http://ieeexplore.ieee.org/abstract/document/7863422/

#sensor #MEMS #fluorescence #sensing

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