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[Conference]High-throughput and label-free parasitemia quantification and stage determination for pl


Abstract:

This work reports a high throughput and label-free cell deformability microfluidic sensor for quantitative parasitemia measurement and stage determination for Plasmodium falciparum-infected red blood cells (Pf-iRBCs). As a mechanical biomarker, the RBC deformability is highly relevant to the infection status. The cell deformability is measured by evaluating the translocation time when each individual cell squeezes through a microscale constriction. More than 30,000 RBCs can be analyzed for parasitemia quantification in under 1 min with a throughput ∼500 cells/s. Moreover, the device can also differentiate various malaria stages (ring, trophozoite, and schizont stage) due to their varied deformability. As compared to the microscopy and flow cytometry, this microfluidic deformability sensor would allow for label-free and rapid malaria parasitemia quantification and stage determination at a low-cost.

Conference: Micro Electro Mechanical Systems (MEMS), 2017 IEEE 30th International Conference on Micro Electro Mechanical Systems (MEMS)

Date of Conference: 22-26 Jan. 2017

Date Added to IEEE Xplore: 28 February 2017

DOI: 10.1109/MEMSYS.2017.7863579

Xiaonan Yang

The Department of Electrical Engineering, Pennsylvania State University, University Park, USA

Zhuofa Chen

The Department of Electrical Engineering, Pennsylvania State University, University Park, USA

Gihoon Choi

The Department of Electrical Engineering, Pennsylvania State University, University Park, USA

Jun Miao

The Department of Entomology, Pennsylvania State University, University Park, USA

Liwang Cui

The Department of Entomology, Pennsylvania State University, University Park, USA

Weihua Guan

The Department of Electrical Engineering, Pennsylvania State University, University Park, USA

Link: http://ieeexplore.ieee.org/abstract/document/7863579/

#MEMS #microchannels #labelfree #RedBloodCell #Biologicalapplication #sensor

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