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[Conference]Fiber-shaped artificial tissue with microvascular networks for bottom-up tissue reconstr


Abstract:

This paper describes a fiber-shaped microscale tissue with blood vessel networks. We co-cultured Hep-G2 (Human hepatic epithelial cell line) and HUVEC (human umbilical endothelial cell) in a collagen/alginate core-shell hydrogel microfiber fabricated by using a microfluidic device. We observed difference in construction of blood vessel networks in the hepatic tissue by varying in the ratio of co-cultured cells and the diameter of the core. In addition, by arranging the fiber-shaped tissues to construct macroscale tissue assembly, we confirmed the connection of blood vessel networks between the assembled fiber-shaped tissues.

Published in: Micro Electro Mechanical Systems (MEMS), 2017 IEEE 30th International Conference on

Date of Conference: 22-26 Jan. 2017

Date Added to IEEE Xplore: 28 February 2017

DOI: 10.1109/MEMSYS.2017.7863387

Ryo Sato

Department of Mechanical Engineering, Faculty of Science and Technology, Keio University, Kanagawa, Japan

Hiroaki Onoe

Department of Mechanical Engineering, Faculty of Science and Technology, Keio University, Kanagawa, Japan

Link: http://ieeexplore.ieee.org/abstract/document/7863387/

#hydrogel #alginate #MEMS #Biologicalapplication

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