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[Conference]Engineering a three-dimensional tissue model with a perfusable vasculature in a microflu


In this study, we developed a microfluidic platform for a three-dimensional tissue model with a perfusable capillary network, which will allow, for the first time, a perfusion-culture in a tissue model with a high cell density. Our group previously reported that a spheroid of lung fibroblasts induced angiogenic sprouts from microchannels [1]. In this study, we successfully connected angiogenic sprouts to the vessel-like hollow structure in a spheroid and perfused the formed vascular network through microfluidic channels to the spheroid. This model opens up new techniques for tissue-culture for long-term.

Published in: Micro Electro Mechanical Systems (MEMS), 2017 IEEE 30th International Conference on

Date of Conference: 22-26 Jan. 2017

Date Added to IEEE Xplore: 28 February 2017

DOI: 10.1109/MEMSYS.2017.7863476

Yuji Nashimoto

Kyoto University, Kyoto, Japan

Itsuki Kunita

Kumamoto University, Kumamoto, Japan

Akiko Nakamasu

Kyushu University, Fukuoka, Japan

Yu-suke Torisawa

Kyoto University, Kyoto, Japan

Masamune Nakayama

Kyoto University, Kyoto, Japan

Hidetoshi Kotera

Kyoto University, Kyoto, Japan

Koichi Nishiyama

Kumamoto University, Kumamoto, Japan

Takashi Miura

Kyushu University, Fukuoka, Japan

Ryuji Yokokawa

Kyoto University, Kyoto, Japan

Link: http://ieeexplore.ieee.org/abstract/document/7863476/

#MEMS #microchannels #Biologicalapplication

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