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[Conference]A practical single cell analysis method for mechanical characterization of cancer cells


Abstract:

This study presents a practical method to perform mechanical characterization of cells using Silicon Nano Tweezers (SNT). Integrated with a microfluidic device, SNT tips were inserted in a channel via a side opening. Cells to be characterized were injected to an inlet of the microfluidic channel and withdrawn by a vacuum pump connected to an outlet. Mechanical properties of a cell, e.g. diameter, stiffness and viscous losses, were analyzed after capturing between the SNT tips (a sensing tip and a compressing tip). After characterization, the captured cell was released to capture another cell. Repeated capturing and characterization steps allow us to test several cells and distinguish fixed and live SUM-159-PT cancer cells based on their mechanical properties.

Published in: Micro Electro Mechanical Systems (MEMS), 2017 IEEE 30th International Conference on MEMS

Date of Conference: 22-26 Jan. 2017

Date Added to IEEE Xplore: 28 February 2017

DOI: 10.1109/MEMSYS.2017.7863481

Tiffany Baëtens

LIMMS/CNRS-IIS, UMI 2820, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan

Grégoire Perret

LIMMS/CNRS-IIS, UMI 2820, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan

Yuki Takayama

CNRS, IIS, COL, Univ. Lille SMMiL-E Project

Momoko Kumemura

LIMMS/CNRS-IIS, UMI 2820, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan

Laurent Jalabert

LAAS-CNRS, Toulouse, France

Samuel Meignan

CNRS, IIS, COL, Univ. Lille SMMiL-E Project

Chann Lagadec

CNRS, IIS, COL, Univ. Lille SMMiL-E Project

Fujita Hiroyuki

CNRS, IIS, COL, Univ. Lille SMMiL-E Project

Dominique Collard

LIMMS/CNRS-IIS, UMI 2820, Institute of Industrial Science, The University of Tokyo, Tokyo, Japan

Mehmet Cagatay Tarhan

CNRS, IIS, COL, Univ. Lille SMMiL-E Project

Link: http://ieeexplore.ieee.org/abstract/document/7863481/

#singlecell #sensor #MEMS #cancer #Biologicalapplication #SiliconNanoTweezers

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