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[Conference]A parylene cuff electrode for peripheral nerve recording and drug delivery


Abstract:

We present a novel polymer-based cuff electrode designed for peripheral nerve recording and drug delivery. The micromachined cuff interface consists of platinum electrodes embedded within Parylene microfluidics. An adjustable locking mechanism ensures close-fitting of the cuff around the nerve for localized drug delivery to induce axonal sprouting from the fascicles towards the embedded electrodes. This Lyse-and-Attract Cuff Electrode (LACE) specifically incorporates drug delivery to improve sensitivity, spatial resolution, fascicle selectivity, and chronic reliability over existing electrode-only interfaces. We present the design, fabrication, and initial testing of fully functional cuffs including evaluation of the locking mechanism, localized drug delivery, and electrochemical properties of recording electrodes.

Published in: Micro Electro Mechanical Systems (MEMS), 2017 IEEE 30th International Conference on MEMS

Date of Conference: 22-26 Jan. 2017

Date Added to IEEE Xplore: 28 February 2017

DOI: 10.1109/MEMSYS.2017.7863454

Angelica M. Cobo

University of Southern California, Los Angeles, California, USA

Barbara Boyajian

University of Southern California, Los Angeles, California, USA

Christopher Larson

University of Southern California, Los Angeles, California, USA

Kee Schotten

University of Southern California, Los Angeles, California, USA

Victor Pikov

Galvani Bioelectronics, UK

Ellis Meng

University of Southern California, Los Angeles, California, USA

Link: http://ieeexplore.ieee.org/abstract/document/7863454/

#drugdelivery #electrode #DrugDelivery #MEMS

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