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Drug Delivery

June 5, 2017

Abstract:

Small interfering RNAs (siRNA) have a broad potential as therapeutic agents to reversibly silence any target gene of interest. The clinical application of siRNA requires the use of safe and effective delivery systems. In this study, we investigated the use of...

May 28, 2017

Abstract:

We report a cell-mediated, targeted drug delivery system utilizing polyelectrolyte multilayer capsules that hybridize with the patient’s own platelets upon intravenous administration. The hybridized platelets function as the sensor and actuator for targeted dr...

May 22, 2017

Abstract:

We demonstrate control of multiscale structure and drug delivery function for paclitaxel (PAX)-loaded polycaprolactone-block-poly(ethylene oxide) (PCL-b-PEO) polymeric nanoparticles (PNPs) via synthesis and flow-directed shear processing in a two-phase gas-liq...

May 20, 2017

Abstract:

Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characteri...

May 15, 2017

Abstract:

Biocompatible microparticles are valuable tools in biomedical research for applications such as drug delivery, cell transplantation therapy, and analytical assays. However, their translation into clinical research and the pharmaceutical industry has been slow...

May 12, 2017

Abstract:

The microfluidic technique has brought unique opportunities toward the full control over the production processes for drug delivery carriers, owing to the miniaturisation of the fluidic environment. In comparison to the conventional batch methods, the microflu...

May 12, 2017

Abstract:

Phospholipid-based deformable nanovesicles (DNVs) that have flexibility in shape offer an adaptable and facile method to encapsulate diverse classes of therapeutics and facilitate localized transdermal delivery while minimizing systemic exposure. Here we repor...

April 25, 2017

Abstract:

Bacteria, including strains of Salmonella, have been researched and applied as therapeutic cancer agents for centuries. Salmonella are particularly of interest due to their facultative anaerobic nature, facilitating colonization of differentially oxygenated tu...

April 13, 2017

Abstract:

Microgels were obtained from the droplets gelation of a water-in-oil emulsion containing gellan in the aqueous phase. Gellan gum (0.6% w/w) and calcium acetate (0.5 and 2.0% w/w) as gelling agent were used to produce the microgels. The effect of the continuous...

April 6, 2017

Abstract:

This paper presents a microfluidic approach for fabricating stereocomplexed hollow microcapsules that uses water-in-oil-in-water double-emulsion droplets as templates. The polylactides functionalized with 2-ureido-4[1H]-pyrimidinone (UPy) end groups are interm...

April 1, 2017

Abstract:

We propose a two-stage integrated optical microfluidic drug delivery/activation system on a monolithic structure for photodynamic single step operation utilizing a dual wavelength selectively intermixed QW LED emitting wavelengths of 800nm and 772nm

Abdullah J....

March 28, 2017

Abstract:

We demonstrate, for the first time, a facile and low-cost approach for integrating highly flexible and stretchable microfluidic channels into textile-based substrates. The integration of the microfluidics is accomplished by means of directly embroidering surfa...

March 17, 2017

PI: Prof. Juan Santiago

Graduate and Postdoctoral Advisors:

Peters, James, Professor, University of Illinois at Urbana-Champaign (M.S. Degree Advisor)

Dutton, J. Craig, Professor, University of Illinois at Urbana-Champaign (Ph.D. Degree Advisor)

Adrian, Ronald J., Profes...

March 13, 2017

Abstract:

Budesonide is a potent active pharmaceutical ingredient, often administered using respiratory devices such as metered dose inhalers (MDI), nebulizers and dry powder inhalers (DPI). Inhalable drug particles are conventionally produced by crystallization followe...

March 13, 2017

Abstract:

This thesis includes three stages of experiments. The goal of the thesis was to prepare nanoparticle-encapsulated curcumin for the purpose of drug delivery. The first step was the nanoparticle preparation. The self-assembly of block copolymer (poly(ε- caprolac...

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