Biological Applications

September 12, 2017

Abstract:

In this work, a layer-by-layer (LbL) assembled biopolymer microcapsule with separate layer cavities is generated by a novel and convenient gas-liquid microfluidic approach. This approach exhibits combined advantages of microfluidic approach and LbL assembly me...

August 22, 2017

Abstract:

Synthetic biology is an interdisciplinary field that aims to engineer biological systems for useful purposes. Organism engineering often requires the optimization of individual genes and/or entire biological pathways (consisting of multiple genes). Advances in...

July 31, 2017

Abstract:

Glioblastoma (GBM) is a highly invasive primary brain tumor that displays cellular heterogeneity, which is composed of glioma initiating cells (GICs) and their differentiated progeny. GICs play an important role in driving aggressive invasion. In particular, t...

July 19, 2017

Abstract:

Recently developed methods that utilize partitioning of long genomic DNA fragments, and barcoding of shorter fragments derived from them, have succeeded in retaining long-range information in short sequencing reads. These so-called read cloud approaches repres...

July 14, 2017

Abstract:

Animal testing is still the most popular preclinical assesment model for liver fibrosis. To develop efficient anti-fibrotic therapies, robust and representative in vitro models are urgently needed. The most widely used in vitro fibrosis model is the culture-in...

July 14, 2017

Abstract:

Analyzing small collections of cells is challenging because of the need for extremely high levels of sensitivity. We recently reported a new approach, termed magnetic ranking cytometry (MagRC), to profile nanoparticle-labeled cells. Using antibody-functionaliz...

July 12, 2017

Abstract:

In this study the application of a newly developed microfluidic immobilized enzymatic reactor (IMER) designed to accelerate protein digestion in clinical samples is presented. The IMER contains trypsin adsorbed on the porous surface of a PDMS microfluidic chip...

July 12, 2017

Abstract:

In addition to inadequate access to early diagnosis and treatment with antimicrobial agents for patients and sexual contacts, management and control of STIs is significantly challenged by emergence and spread of antimicrobial resistance (AMR), particularly for...

July 10, 2017

Abstract:

Salivary diagnostics is an emerging field for the encroachment of point of care technology (PoCT). The necessity of the development of point-of-care (PoC) technology, the potential of saliva, identification and validation of biomarkers through salivary diagnos...

July 10, 2017

Abstract:

Metagenomics and single-cell genomics have enabled genome discovery from unknown branches of life. However, extracting novel genomes from complex mixtures of metagenomic data can still be challenging and represents an ill-posed problem which is generally appro...

July 10, 2017

Abstract:

Droplet microfluidics has found use in many biological assay applications as a means of high-throughput sample processing. One of the challenges of the technology, however, is the ability to control and merge droplets on-demand as they flow through the microde...

July 8, 2017

Abstract:

Even though the diagnostic and prognostic value of circulating tumor cells (CTCs) have been demonstrated, their clinical utility and widespread adoption have been limited. Herein, we describe a new device, Size Dictated Immunocapture Chip (SDI-Chip), for effic...

July 8, 2017

Abstract:

Myelin formation has been identified as a modulator of neural plasticity. New tools are required to investigate the mechanisms by which environmental inputs and neural activity regulate myelination patterns. In this study, we demonstrate a microfluidic compart...

July 8, 2017

Abstract:

Neutrophil migration and chemotaxis are critical for our body's immune system. Microfluidic devices are increasingly used for investigating neutrophil migration and chemotaxis owing to their advantages in real-time visualization, precise control of chemical co...

July 3, 2017

Abstract:

Despite frequent herpes simplex virus (HSV) reactivation, peripheral nerve destruction and sensory anesthesia are rare. We discovered that skin biopsies obtained during asymptomatic human HSV-2 reactivation exhibit a higher density of nerve fibers relative to...

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